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. 2021 Apr 7;593(7857):101–107. doi: 10.1038/s41586-021-03420-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — a, b, Repeat structure, α-satellite organization, methylation status and sequence identity heat map of the maternal (a) and paternal (b) chromosome 8 centromeric regions from a diploid human genome (HG00733; Supplementary Table 2) shows structural and epigenetic similarity to the CHM13 chromosome 8 centromeric region (Fig. 2a). c–e, Dot plot comparisons between the CHM13 and maternal (c), CHM13 and paternal (d), and maternal and paternal (e) chromosome 8 centromeric regions in the HG00733 genome show more than 99% sequence identity overall, with high concordance in the unique and monomeric α-satellite regions of the centromeres (dark red line) that devolves into lower sequence identity in the α-satellite HOR array, consistent with rapid evolution of this region.