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. 2021 Apr 7;593(7857):101–107. doi: 10.1038/s41586-021-03420-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — a, HOR composition and organization of the chromosome 8 α-satellite array as determined via StringDecomposer⁴². The predominant HOR subtypes (4-, 7-, 8- and 11-monomer HORs) are shown, whereas those occurring less than 15 times are not (see Methods for absolute quantification). The entropy of the D8Z2 HOR array is plotted in the bottom panel and reveals that the hypomethylated and CENP-A-enriched regions have the highest consistent entropy in the entire array. b, Organization of α-satellite monomers within each HOR. The initial monomer of the 4- and 7-monomer HORs is a hybrid of the A and E monomers, with the first 87 bp the A monomer and the subsequent 84 bp the E monomer. c, Abundance of the predominant HOR types within the D8Z2 HOR array as determined via StringDecomposer⁴².