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. 2021 Apr 7;593(7857):101–107. doi: 10.1038/s41586-021-03420-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — a, Coverage of CHM13 ONT and PacBio HiFi data along the CHM13 β-defensin locus (top two panels). The ONT and PacBio data have largely uniform coverage, indicating it is free of large structural errors. The dip in HiFi coverage near position 10.46 Mb is due to a G/A bias in HiFi chemistry⁵. The alignment of 47 CHM13 BACs (bottom) reveals that those regions have an estimated quality value score >25 (>99.7% accurate). b, Copy number of DEFA (chr8:6976264−6995380 in GRCh38 (hg38)) throughout the human population. Median ± s.d. is shown.