Figure 3.

Rod-mediated vision improves in treated eyes of patients with GUCY2D-LCA.

Dark-adapted chromatic full-field stimulus test (FST) results in P1, P2, and P3.

(A) Sensitivity changes from baseline for the short-wavelength stimulus, shown separately for untreated and treated eyes. In the treated eye, P1 had improvements greater than 1.0 log unit at all post-operative visits; P2 reached 0.78 l.u. at the last visit. P3 did not show improvement. Sensitivity levels at baseline are indicated in log₁₀(1/cd.m⁻²) to the left of the zero-change dashed line.

(B) Change in sensitivity from baseline in treated (up-triangles) and untreated (down-triangles) eyes for the photopically matched targets (blue and red lines, respectively for short and long wavelength). Localization of up-triangles above down-triangles indicates a post-treatment improvement of the treated eye relative to the untreated eye. Green arrows indicate interocular differences with respect to baseline; there is an asterisk when significantly different than zero (α = 0.05, eye/visit interaction term in a linear model).

(C) Chromatic difference between sensitivities to the two targets (short-minus long-wavelength, blue minus red). Differences near 2.54 log₁₀ indicate rod mediation (rods detecting both colors); values near zero would imply cone mediation. Rod mediation was observed in both eyes of the three patients at all visits. BL, baseline visit.