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. 2020 Jun 25;478(5):1007–1012. doi: 10.1007/s00428-020-02869-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Genome-wide copy number plots calculated from microarray data for the five closest UMAP neighbor cases, all representing squamous cell cancers of the lung. All neighboring cases are TCGA datasets. Note multiple complex copy number alterations in all cases, distinguishing conventional lung squamous cell cancer from the fusion-driven NUT midline carcinoma despite the epigenomic similarities between these entities