Table 2.
Absolute changes in MMSE, attention and executive function, TMT, VFT and CES-D by treatment
| Week 160a | End of follow-upb | |||
|---|---|---|---|---|
| Linagliptin (n = 1618) |
Glimepiride (n = 1545) |
Linagliptin (n = 1618) |
Glimepiride (n = 1545) |
|
| MMSE score | ||||
| Baseline | 28.5±1.7 | 28.5±1.7 | 28.5±1.7 | 28.5±1.7 |
| Follow-up | 28.2±2.1 | 28.3±2.2 | 28.1±2.7 | 28.1±2.7 |
| Change from baseline | −0.2±2.0 | −0.2±2.1 | −0.4±2.6 | −0.4±2.6 |
| A&E (z score)c | ||||
| Baseline | −0.01±0.70 | 0.01±0.01 | −0.01±0.70 | 0.01±0.01 |
| Follow-up | −0.06±0.73 | −0.05±0.71 | −0.10±0.77 | −0.09±0.78 |
| Change from baseline | −0.05±0.74 | −0.06±0.72 | −0.11±0.81 | −0.14±0.81 |
| VFT letter 60 (in seconds)d | ||||
| Baseline | 9.2±4.2 | 9.3±4.1 | 9.2±4.2 | 9.3±4.1 |
| Follow-up | 8.9±4.0 | 9.1±4.0 | 9.1±4.3 | 9.1±4.5 |
| Change from baseline | −0.2±2.6 | −0.2±2.7 | −0.2±2.9 | −0.2±3.4 |
| VFT animals 60 (in seconds)e | ||||
| Baseline | 16.1±6.6 | 16.0±6.2 | 16.1±6.6 | 16.0±6.2 |
| Follow-up | 15.6±6.6 | 15.6±6.5 | 15.7±7.5 | 15.4±7.1 |
| Change from baseline | −0.5±6.0 | −0.4±5.7 | −0.6±7.4 | −0.6±6.7 |
| Overall VFT 60 (z score) | ||||
| Baseline | −0.01±0.89 | 0.002±0.85 | −0.01±0.89 | 0.002±0.85 |
| Follow-up | −0.09±0.84 | −0.07±0.84 | −0.06±0.96 | −0.08±0.96 |
| Change from baseline | −0.07±0.63 | −0.06±0.64 | −0.07±0.78 | −0.09±0.76 |
| TMT-A (in seconds) | ||||
| Baseline | 51.2±28.1 | 50.4±26.7 | 51.2±28.1 | 50.4±26.7 |
| Follow-up | 53.7±30.3 | 53.3±30.6 | 54.1±30.6 | 55.4±33.3 |
| Change from baseline | 2.1±24.2 | 2.8±25.4 | 3.4±25.6 | 4.4±28.1 |
| TMT-B (in seconds) | ||||
| Baseline | 113.1±57.8 | 111.8±61.3 | 113.1±57.8 | 111.8±61.3 |
| Follow-up | 118.2±64.4 | 118.3±63.8 | 125.5±67.7 | 125.3±66.0 |
| Change from baseline | 7.1±53.9 | 9.8±54.1 | 15.2±63.3 | 18.2±59.5 |
| TMT ratiof | ||||
| Baseline | 1.4±1.0 | 1.4±1.0 | 1.4±1.0 | 1.4±1.0 |
| Follow-up | 1.4±1.0 | 1.4±1.0 | 1.6±1.1 | 1.5±1.0 |
| Change from baseline | 0.1±1.1 | 0.2±1.1 | 0.2±1.3 | 0.3±1.0 |
| CES-D score | ||||
| Baseline | 8.7±8.0 | 9.3±8.3 | 8.7±8.0 | 9.3±8.3 |
| Follow-up | 10.5±9.9 | 11.4±10.6 | 10.2±9.9 | 10.6±9.6 |
| Change from baseline | 1.7±9.6 | 2.1±10.4 | 1.6±9.6 | 1.4±10.0 |
Data are mean±SD
Time between randomisation and visit: median (min–max): a3.07 (0.02–3.19), b6.40 (3.20–7.42) years
cA&E, composite z score for attention and executive functioning
dVFT letter 60: averaged VFT scores for the letters F, A and S in 60 s
eVFT animals 60: VFT score for the category animals in 60 s
fTMT ratio: (TMT-B − TMT-A)/TMT-A