Table 1.
Regions with a co-localisation posterior probability of ≥0.9 between type 1 diabetes and type 2 diabetes
| rsID | Proximal gene(s) | chr | pos (gr37) | REF | ALT | T2D conditional on: | T2D OR (95% CI) | T2D p | r2 to T1D index variant (T1D index variant) | T1D conditional on: | T1D OR (95% CI) | T1D p |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs2269247 | PGM1 | 1p31.3 | 64107284 | C | T | – | 0.96 (0.94, 0.97) | 4.60×10-7 | 0.86 (rs2269246) | – | 1.14 (1.08, 1.22) | 1.94×10-6 |
| rs56337234 | TMEM129 | 4p16.3 | 1784403 | C | T | – | 0.94 (0.93, 0.96) | 1.40×10-17 | 0.97 (rs6829631) | – | 1.12 (1.07, 1.18) | 4.07×10-6 |
| rs4929965 | INS | 11p15.5 | 2197286 | G | A |
rs11042596, rs555759341, rs571342427, rs10838787 |
1.07 (1.06, 1.09) | 4.80×10-25 | 0.97 (rs7119275) | rs689 | 0.87 (0.81, 0.93) | 1.89×10-5 |
| rs72802342 |
CTRB1/ BCAR1 |
16q23.1 | 75234872 | C | A | rs3115960 | 0.87 (0.85, 0.89) | 4.00×10-32 | 0.89 (rs55993634) | – | 1.33 (1.22, 1.46) | 5.81×10-10 |
Summary statistics given from the perspective of the index type 2 diabetes variant and with respect to the ALT allele
r2 obtained from 1000 Genomes Project European population
ALT, alternative allele; REF, reference allele; T2D, type 2 diabetes; T1D, type 1 diabetes
The OR is for the addition of an ALT allele