Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 5;12:2539. doi: 10.1038/s41467-021-22759-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — a Summary of phosphosite and protein-level identification results in each tumor (T) and adjacent normal (N) lung cancer tissue. b Principal component (PC) analysis of tumor and adjacent normal tissues using differentially expressed sites normalized to protein level (two-sampled t-test, p < 0.05, S0 = 0.1). c Unsupervised clustering of 585 (normalized) differentially expressed phosphosites between tumor and normal tissues (two-sampled t-test, p < 0.05, S0 = 0.1). d Pathway analysis of upregulated phosphosites by the Kyoto Encyclopedia of Genes and Genomes (KEGG) database (FDR < 0.05). e Differentially expressed phosphosites showing increasing or decreasing expression between early and late stages (two-sampled t-test, p < 0.05, S0 = 0.1). Protein–protein interaction network and functional category of phosphoproteins for f upregulated in the early and g upregulated in late stages filtered with medium confidence and FDR < 0.05 in STRING database (https://string-db.org/). Source data are provided as a Source Data file.