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. 2021 May 6;7:94. doi: 10.1038/s41420-021-00478-0

Fig. 6. SDF4 is positively correlated with VEGF-D and the endothelial cell marker CD31 expression and poor survival of lung cancer patients treated with cisplatin.

Fig. 6

A Tissue specimens from 57 patients with lung cancer treated with or without cisplatin were stained for SDF4 expression. SDF4 was positively correlated with fibroblasts in cisplatin-treated lung cancer patients. B, C SDF4, VEGF-D, and CD31 staining was performed via IHC with their individual specific antibodies. SDF4 abundance was correlated with VEGF-D and CD31 signals in 57 lung cancer patients. D Correlation between SDF4 abundance and the survival rate of cisplatin-treated lung cancer patients. Differences between patient subsets in overall survival were determined via Kaplan–Meier plot analysis and log-rank tests. A two-tailed p < 0.05 was considered statistically significant. Statistical analysis was performed with SPSS v. 17.0 software (SPSS, USA).