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. 2021 May 5;11:9588. doi: 10.1038/s41598-021-88887-0

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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SFV transduced astrocytes are morphologically and antigenically distinct from OL. (Ai,Bi) mCherry-f labelled glia in cerebellar white matter exhibiting complex finely branching process fields typical of astroglia. (Aii,Bii) Enlarged view of the boxed areas shown in (Ai)/(Bi) showing the major white matter paths (dashed white lines) with MBP⁺ OL processes (green) branching into the granule cell layer. (Aiii,Biii). Merged image showing mCherry-f fluorescence and MBP immunoreactivity from the same enlarged views shown in (Aii)/(Bii). White dashed lines indicate major white matter paths. In contrast to OL (Fig. 1) SFV labelled astrocytes lack cellular processes aligned in parallel with the major white matter tracks, or linear segments of MBP/process localization. Astrocytes exhibit patches of MBP co-localization (*) suggesting contact with MBP⁺ profiles within cerebellar white matter. Scale bars in all panels 20 µm.