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. 2021 May 5;11:9588. doi: 10.1038/s41598-021-88887-0

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Sustained inhibition of neuronal activity reduces myelination of cerebellar white matter. (A,B) Maximum projection images from representative control (A) and TTX (B) treated cerebellar slices showing immunofluorescent signals for anti-NF200 (Ai,Bi) anti-MBP (Aii,Bii), and co-localisations used to quantify myelination (Aiii,Biii). (C) Quantification of anti-NF200 signals. Mean NF200 pixel fraction is reduced by TTX (Control 20.4 ± 0.7, TTX 17.9 ± 0.7). (D) Average MBP/NF200 ratios normalized against the NF200 signal are significantly reduced by TTX (Control 0.4 ± 0.02, TTX 0.29 ± 0.02). Scale bars in (A) and (B) 20 µm. * and ** Significance P < 0.05 and P < 0.01, respectively. Data expressed as means ± SEM.