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. 2021 May 5;11:9588. doi: 10.1038/s41598-021-88887-0

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Sustained inhibition of neuronal activity alters OL morphology. (A,B) Representative 3-D reconstructions of OL from control (A) and TTX (B) treated cerebellar slices showing internodes selected for quantification (A cyan, blue, green, red; B blue, green, red) and cell bodies (yellow circles). (C) Tendency towards an increased numbers of branches per cell for TTX treated _TOL (Control 20.5 ± 1.15, TTX 24.6 ± 1.86). (D) TTX treatment reduced the median internode length of _TOL (Control 84.7 µm (68.6–101), TTX 53.8 µm (39.3–81.2). (E,F) TTX treatment induced complementary changes in the ratio _NMPB/TB (E) (Control 0.72 ± 0.02, TTX 0.80 ± 0.02) and _MPB/TB (F) (Control 0.28 ± 0.02, TTX 0.20 ± 0.02). Scale bars in (A) and (B) 20 µm. ** Significance P < 0.01, *** Significance P < 0.001. In (A) and (B) red and blue spheres indicate segment end-point and junction points respectively. Yellow circles indicate position of cell body. Data in (C), (E) and (F) expressed as means ± SEM, data in (D) expressed as median ± interquartile range.