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. 2021 May 5;11:9534. doi: 10.1038/s41598-021-88716-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Kaplan–Meier curves and Log-rank test show associations of ENE in ALN with DRFS and OS in whole patients with different nodal (N) stage. (A,B) Comparison of survival rate for DRFS (ENE negative group vs. ENE positive group: p = 0.557) (A) and OS (ENE negative group vs. ENE positive group: p = 0.547) (B) between different ENE groups in patients with N1 stage. (C,D) Comparison of survival rate for DRFS (ENE negative group vs. ENE positive group: p = 0.919) (C) and OS (ENE negative group vs. ENE positive group: p = 0.367) (D) between different ENE groups in patients with N2 stage. (E–F) Comparison of survival rate for DRFS (ENE negative group vs. ENE positive group: p = 0.047) (E) and OS (ENE negative group vs. ENE positive group: p = 0.346) (F) between different ENE groups in patients with N3 stage.