Table 3.
Changes in the clinical parameters
| 0 week | 12 weeks | 52 weeks | P value (0 vs. 12 weeks) | P value (0 vs. 52 weeks) | |
|---|---|---|---|---|---|
| BMI (kg/m2) | 24.3 ± 3.1 | 23.6 ± 3.0 | 23.3 ± 3.0 | 0.001 | 0.006 |
| SBP (mmHg) | 125.0 ± 14.2 | 122.5 ± 13.0 | 122.8 ± 11.8 | 0.626 | 0.729 |
| DBP (mmHg) | 72.0 ± 9.5 | 68.5 ± 12.3 | 70.2 ± 8.9 | 0.236 | 0.566 |
| FPG (mg/dL) | 170.4 ± 66.6 | 148.2 ± 40.8 | 177.1 ± 51.7 | 0.288 | 0.619 |
| HbA1c (%) | 7.79 ± 0.94 | 7.30 ± 0.86 | 7.55 ± 0.67 | 0.002 | 0.271 |
| AST (U/mL) | 20.2 ± 5.7 | 26.4 ± 22.0 | 25.3 ± 17.7 | 0.769 | 0.411 |
| ALT (U/mL) | 18.2 ± 8.2 | 18.4 ± 7.1 | 22.3 ± 15.6 | > 0.999 | > 0.999 |
| Creatinine (mg/dL) | 0.93 ± 0.53 | 0.93 ± 0.51 | 0.91 ± 0.49 | > 0.999 | > 0.999 |
| eGFR | 73.3 ± 22.5 | 73.4 ± 23.4 | 72.5 ± 21.9 | > 0.999 | > 0.999 |
| UACR (mg/gCre) | 13.4 (6.2 to 33.6) | 10.2 (7.2 to 21.9) | 9.5 (6.2 to 31.9) | 0.512 | 0.583 |
| Total insulin (unit/day) | 42.2 ± 14.5 | 37.8 ± 15.3 | 40.1 ± 15.3 | 0.060 | 0.404 |
| Basal insulin (unit/day) | 15.0 ± 7.2 | 13.8 ± 7.1 | 12.4 ± 7.0 | 0.089 | 0.002 |
| Bolus insulin (unit/day) | 27.2 ± 8.8 | 23.9 ± 10.5 | 27.6 ± 11.0 | 0.064 | 0.956 |
SBP systolic blood pressure, DBP diastolic blood pressure, FPG fasting plasma glucose, AST alanine aminotransferase, ALT aspartate aminotransferase, eGFR estimated glomerular filtration rate, UACR urine albumin creatinine ratio
All data are presented as mean ± SD, but UACR is median (interquartile range)