Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Apr 22;8:603374. doi: 10.3389/fmed.2021.603374

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Seow, Pai, Mishra, Shepherdson, Lim, Goh, Chan, Chow, Ginhoux, DasGupta and Sharma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Co-enrichment of ACE2, TMPRSS2, and EPCAM in liver epithelial cells. RNA-FISH-based detection of ACE2, TMPRSS2, and EPCAM in (A,B) adjacent normal, (C,D) fatty liver, and (E,F) tumor tissues. (G) Quantification of RNA-FISH images. (H) Schematic of TROP2 expression level and cell fate choices in adult human liver progenitor cells. TROP2^high cells express genes exhibiting cholangiocyte fate bias. TROP2^high cells also express a higher level of ACE2 and TMPRESS2, making these cells more susceptible for SARS-CoV-2 infection, indicating implications in COVID-19-associated liver dysfunctions. *means statistical significance of P < 0.05.