Table 4.

Gene ontology results using 255 DE lncRNAs.

GO Ida	Labelb	Ratioc	P-value	Fold enrichmentd	Genese
CELLULAR COMPONENT
GO:0070062	Extracellular exosome	31.75	3.18e-25	37.53	ACOT9, ADAD1, AHR, AKAP12, ALCAM, ALG12, AMELX, AMER1, ATXN7, B4GALT4, BCL2, BEX3, BOD1, CBX3, CCDC174, CCNO, CEACAM1, CMTR2, CNOT11, COQ8B, DENND4B, DFFA, DPH1, EBF3, FLRT2, FOXJ2, FTH1, GALNT6, GLB1L3, IRF2BPL, KAT2B, KIRREL3, KLHL9, NR3C1, NRIP1, PLEKHM1, POLR1B, SAMD9, SLC2A8, SLC48A1, TWISTNB, ZSCAN4, CA8, UPK1A
GO:1903561	Extracellular vesicle	27.40	5.63e-24	32.39
GO:0043230	Extracellular organelle	25.97	1.59e-23	30.71
GO:0043227	Membrane-bounded organelle	1.36	2.86e-16	1.61
GO:0043226	Organelle	1.28	6.34e-16	1.51
GO:0005622	Intracellular	1.21	5.43e-15	1.42
GO:0031982	Vesicle	2.83	1.57e-13	3.34
GO:0005737	Cytoplasm	1.32	2.27e-12	1.56
GO:0043229	Intracellular organelle	1.24	3.84e-12	1.46
MOLECULAR FUNCTION
GO:0005515	Protein binding	2.29	1.15e-44	2.70	CCNO, CCR6, CCSAP, CDA, CDH11, DFFA, DOK5, DPH1, EBF3, ENPP2, ICE2, IFNAR1, IL12B, IL7R, IQSEC1, MAP3K7CL, NBR1, POLR1B, PPP2R5A, PRDM1, PRKAR2B, PTS, RHOU, RNF122, RPE, RRAGB, SAE1, SAMD14, SAMD9, SBSN, SCGB1A1, SESTD1, SH3D19, SLC48A1, SNX24, SNX32, SOD1, SPIN2, SPNS3, STOM, TLR5, TMEM19, TMEM74, TMEM9, TOP1, TRMT12, ELMSAN1, GALNT6, PCDH7, ZNF518A, SAE, ZNF350, NBR1, TMEM74, TWSG1, IQSEC1, B4GALT4, CDA, PPP2R5A
GO:0005488	Binding	1.37	3.18e-24	1.62
GO:0046872	Metal ion binding	1.57	4.98e-06	1.85
GO:0043169	Cation binding	1.53	9.96e-06	1.81
GO:0043167	Ion binding	1.34	1.10e-05	1.58
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	2.12	1.16e-04	2.5
GO:0000987	cis-Regulatory region sequence-specific DNA binding	2.07	1.56e-04	2.44
GO:0043565	Sequence-specific DNA binding	1.81	1.57e-04	2.14
GO:0003677	DNA binding	1.59	2.03e-04	1.88
BIOLOGICAL PROCESSES
GO:0043312	Neutrophil degranulation	75.00	7.08e-12	141.90	ATP6AP2, CDA, CEACAM1, FTH1, MMP25, STOM, AHR, AKAP12, AMELX, AMER1, APPL1, ATXN7, BCL2, BEX3, BOD1, CBX3, CCNO, CNOT11, CREB3L3, CREB3L4, DFFA, DOK5, DPH1, EBF3, ELMSAN1, ENPP2, ERI1, FOXJ2, FZD1, GRSF1, H2AFZ, HIVEP3, HMG20A, HOMEZ, IBTK, ICE2, IL12B, IL7R, IRF2BPL, KAT2B, LARP4B, LBX1, LOXL2, LPXN, LSM2, MOSPD1, MYBL2, NBR1, NR3C1, NRIP1, OXR1, PDE4B, PIK3R4, PKHD1, POLR1B, PPP2R5A, PRKAR2B, PUM3, RAD50, RAF1, RBBP6, RBM12B, RRAGB, SAE1, SCGB1A1, SH3D19, SNX32, SOD1, SPIN2, SPTLC2, TAZ, TEAD4, TIRAP, TLR5, PAG1, SLC2A8, SNRK, ZFAND5, PRDM1
GO:0019222	Regulation of metabolic process	1.53	1.25e-10	1.80
GO:0002283	Neutrophil activation involved in immune response	60.00	4.38e-10	70.95
GO:0050789	Regulation of biological process	1.22	8.09e-10	1.43
GO:0031323	Regulation of cellular metabolic process	1.55	9.18e-10	1.83
GO:0050794	Regulation of cellular process	1.22	2.46e-09	1.44
GO:0002446	Neutrophil-mediated immunity	42.86	3.20e-09	50.67
GO:0060255	Regulation of macromolecule metabolic process	1.51	3.81e-09	1.78
GO:0065007	Biological regulation	1.17	4.04e-09	1.38
GO:0048518	Positive regulation of biological process	1.53	7.12e-09	1.81
GO:0051171	Regulation of nitrogen compound metabolic process	1.53	1.04e-08	1.80
GO:0042119	Neutrophil activation	30.00	2.61e-08	35.47
GO:0080090	Regulation of primary metabolic process	1.49	3.38e-08	1.76
GO:0043299	Leukocyte degranulation	28.57	3.47e-08	33.78

^aId: gene ontology (GO) symbol accepted by the broader scientific community and sorted by ascending p-value.

^bLabel: GO term accepted by the broader scientific community.

^cRatio: the proportion of genes submitted and those found to be associated with the GO term.

^dFold enrichment: statistical estimation of obtaining the GO term that is not attributed to random chance.

^eGenes: a snippet of genes associated with the GO domain, more detailed genes available in Supplementary File 1. Genes found expressed in bovine macrophages are in bold characters.