Table E3.

Most significant association results for amino acids in HLA molecules and risk of immediate hypersensitivity to penicillins

Marker		MAF		Association analysis		Association conditioned for glutamate-10		Association conditioned for HLA haplotype
Position	AA	Cases	Controls	OR (95% CI)	P value	OR (95% CI)	P value	OR (95% CI)	P value
10	E	0.03	0.008	2.72 (1.81-4.09)	.000001	—	—	—	—
30	R	0.03	0.008	2.67 (1.78-4.01)	.000002	—	—	—	—
31	V	0.03	0.008	2.67 (1.78-4.01)	.000002	—	—	—	—
38	A	0.03	0.008	2.67 (1.78-4.01)	.000002	—	—	—	—
40	Y	0.03	0.008	2.67 (1.78-4.01)	.000002	—	—	—	—
231	P	0.03	0.008	2.53 (1.68-3.8)	.000008	—	—	0.4 (0.04-4.2)	.44
166	Q	0.03	0.008	2.52 (1.68-3.79)	.000009	—	—	—	—
11	V	0.17	0.15	1.42 (1.19-1.69)	.00008	1.28 (1.06-1.55)	.008	1.29 (1.07-1.55)	.008
37	Y	0.41	0.3	1.27 (1.11-1.44)	.0004	1.21 (1.06-1.38)	.005	1.21 (1.06-1.38)	.005