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. 2021 May 5;12:2536. doi: 10.1038/s41467-021-22913-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Fluorescence images showing elevated levels of 8 EV protein markers (CA 15-3, CA 125, CEA, HER2, EGFR, PSMA, EpCAM, and VEGF) in plasma samples from a MBC patient (HR + subtype) and a NMBC patient (HER2 + subtype) compared to HD. Images are shown from a single measurement. Scale bar, 50 μm. b Radar plot showing TAS analyses of eight EV protein markers from MBC (red dots), NMBC (blue dots), and HD (gray dots). c Heatmap of EV protein profiles from 36 MBC patients, 21 NMBC patients, and 66 HD. d Precision-Recall Curves (PRC) for single EV protein markers to differentiate between BC and HD, as well as MBC and NMBC. e Summary of AUPRC (area under the PRC) of single EV protein markers for BC versus HD discrimination and MBC versus NMBC discrimination. f Pearson correlation matrix showing weak correlations between any pair of EV protein markers, as well as between EV markers and plasma CA 15-3. Plasma CA 15-3 is represented as P CA 15-3. Pearson correlation coefficient (r) is indicated. Source data are provided as a Source Data file.