Fig. 6. Comparison of the EV^M signature and plasma CA 15-3 in longitudinal monitoring for MBC.

The EV^M signature, CA 15-3 level, and therapeutic response were summarized for MBC patients in different BC subtypes (n = 5 for each subtype). The cumulative sum of the EV^M signature at each time point was calculated and plasma CA 15-3 level was normalized by the cutoff value of 25 U mL⁻¹. The solid gray, green, blue, and red dots indicate the EV^M signature at the baseline, PR, SD, and PD, respectively. The void gray, green, blue, and red dots indicate the plasma CA 15-3 at the baseline, PR, SD, and PD, respectively. Source data are provided as a Source Data file.