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. 2021 May 5;11:9544. doi: 10.1038/s41598-021-89149-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of EMPA on left ventricular function. Effects of EMPA on (a) left ventricular ejection fraction, left ventricular volumes in (b) end systole and (c) end diastole were assessed by echocardiography in PLACEBO-Post (n = 7), EMPA-Chronic (n = 6), EMPA-Post (n = 8), PLACEBO SHAM (n = 7) and EMPA SHAM (n = 7). EF ejection fraction, LV Vol_s left ventricular volume in the systole, LV Vol_d left ventricular volume in the diastole. Mean ± SD. Statistical significance is shown as * p < 0.05, *** p < 0.001.