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. 2021 May 5;12:2540. doi: 10.1038/s41467-021-22801-0

Fig. 3. Phenotypes of lung epithelial cells and their evolutionary trajectory into cancer cells.

Fig. 3

a UMAP projection of alveolar cells. Alveolar cells could be further divided into two clusters, both of which are AT2 cells. They were denoted as AT2-1 and AT2-2. b Volcano plot of differentially expressed genes between AT2-1 and AT2-2 cells. Difference between percentage of cells expressed in two clusters was plotted against log fold change of average expressions. c UMAP visualization of epithelial cell subtypes. Epithelial cells could be further annotated into basal cells, club cells, and ciliated cells. d Heatmap of canonical marker genes of epithelial lung subtypes. e Developmental trajectories of AT2 cells, club cells, and LUAD tumor cells. Normal cells were shown as a whole for each type, and cancer cells were shown separately for each patient. f Developmental trajectories of basal cells, club cells, and LUSC tumor cells.