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. 2021 May 5;12:2535. doi: 10.1038/s41467-021-22869-8

Fig. 5. Quality of the predicted tertiary structures for CASP13 FM target proteins.

Fig. 5

a ProFOLD predicted more high-quality structures than the state-of-the-art approaches. When using the popular cut-off threshold for high-quality structures (TMscore ≥0.70), ProFOLD predicted high-quality structures for 18 out of the 31 domains, whereas AlphaFold and trRosetta predicted high-quality structure for only 12 and 7 domains, respectively. b Head-to-head comparison clearly demonstrates the advantages of ProFOLD over AlphaFold: for 24 out of the 31 FM domains, ProFOLD outperformed AlphaFold.