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. 2021 Apr 22;14:658465. doi: 10.3389/fnmol.2021.658465

Figure 1.

Figure 1

Long-term potentiation (LTP) at ventral hippocampal CA1—subiculum synapses is enhanced following acute stress in adulthood. (A) Study design. Schematic drawing on the right illustrates the placement of the stimulation and recording electrodes in the hippocampal slice and the calculation of the population spike (PS) amplitude. (B) Time course of mean normalized PS amplitudes at CA1—subiculum synapses. LTP in the subicular field following high-frequency stimulation (HFS, 100 Hz, arrow) is significantly enhanced in stressed rats. Inset shows sample PS traces before (base, min 6–10) and after (post, min 36–40) HFS, scale bars: amplitude normalized to baseline of control, 50 ms. (C) Quantification of mean normalized PS amplitudes (control: n = 15/10, paired Student’s t-test, ***p < 0.001; stress: n = 12/6, Wilcoxon signed ranked test, ***p < 0.001; control vs. stress, unpaired Student’s t-test, *p < 0.05).