Figure 9.

Comparison between “reactivation hypothesis” and “stochastic expression hypothesis”. (A) Consequences on the temporal order of viral gene expression and on recurrence of infectious virus. (B) Consequences on antigen presentation for driving MI. IE, immediate-early phase or protein; E, early phase or protein; L, late phase or protein; vRAP, (negative) viral regulator of antigen presentation, iTEM, inflationary effector-memory CD8⁺ T cells; MI, memory inflation. Grey circles, silenced circularized viral genomes in the nucleus of latently infected non-hematopoietic tissue cells. Color-coded boxes: viral transcripts and proteins. Receptor symbols on tissue cells and on iTEM represent antigenic peptide-presenting MHC class-I molecules and T-cell receptors, respectively.