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. 2021 Apr 22;12:665901. doi: 10.3389/fimmu.2021.665901

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Copyright © 2021 Zhou, He, Xie, Zhou, Zeng, Li and Huang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heatmap and metabolic network analysis of the identified metabolites. (A) Heatmaps of the differential metabolites that were altered by CTX compared with AGP_AGG mice. Asterisks represent metabolites whose abundance in CTRL mice was altered by CTX and then regulated by AGP_AGG. (B) The profile of metabolic network analysis of the identified metabolites based on the known metabolic pathways. Red color represents significantly increased metabolites in CTX group, while green represents decreased dramatically, compared to CTRL group. “↑↓” describes metabolites that were significantly up- or down-regulated after AGP_AGG treatment. FFA, free fatty acid; AC, acylcarnitine; CTRL, control group; CTX, cyclophosphamide-induced immunosuppressive group; AGP_AGG, American ginseng polysaccharide+American ginseng ginsenoside with cyclophosphamide-induced immunosuppressive group.