Table 1.

Pattern recognition receptors in epithelial and innate immune cells that recognise C. albicans pathogen-associated molecular patterns.

PRR family	PRR	Fungal PAMP	Expressed in	Reference
TLRs	TLR2	Phospholipomannans	Neutrophils, macrophages, DCs, Epithelial cells (oral, vaginal, intestinal)	(Kurt-Jones et al. 2002; Jouault et al. 2003; Fazeli, Bruce and Anumba 2005; Décanis, Savignac and Rouabhia 2009; McClure and Massari 2014)
	TLR4	O-linked mannans	Neutrophils, monocyte, macrophages, DCs, epithelial cells (oral, vaginal, intestinal)	(Netea et al. 2006; Hyung Sook Kim et al. 2016; Fazeli, Bruce and Anumba 2005; Weindl et al. 2007; McClure and Massari 2014)
	TLR9	Fungal DNA Chitin	DCs, Neutrophils, macrophages, epithelial cells (oral, vaginal, intestinal)	(Miyazato et al. 2009; Kasperkovitz et al. 2011; McClure and Massari 2014; Wagener et al. 2014)
CLRs	Dectin-1	β-glucans	Macrophages, monocytes, neutrophils, DCs, epithelial cells (oral, intestinal)	(Brown and Gordon 2001; Brown et al. 2002; Taylor et al. 2002; Ariizumi, Shen, Shikano, Xu et al. 2000; Cohen-Kedar et al. 2014)
	Dectin-2	Mannoproteins (a-mannans)	Macrophages, DCs	(Taylor et al. 2005; Ariizumi, Shen, Shikano, Ritter, et al. 2000)
	Dectin-3	Mannoproteins (a-mannans)	Macrophages,	(Zhu et al. 2013)
	DC SIGN	Mannoproteins	Macrophages, DCs	(Cambi et al. 2003; Rappocciolo et al. 2006)
	Mincle	Mannoproteins	Neutrophils, macrophages, DCs	(Wells et al. 2008; Vijayan et al. 2012; Martínez-López et al. 2019)
	MR	Mannoproteins Chitin	DCs, macrophages	(van de Veerdonk et al. 2009; Martinez-Pomares 2012; Wagener et al. 2014)
NA	EphA2	β-glucans	Oral epithelial cells, neutrophils	(Swidergall, Solis, et al. 2019)
	Galectin-3	β-mannosides	Monocytes, macrophages, DCs, neutrophils, epithelial cells	(Jouault et al. 2006)
RLRs	MDA5	Unknown	Monocytes, DCs, macrophages, epithelial cells	(Plato, Hardison and Brown 2015)
NLRs	NOD2	Chitin	Monocytes, DCs, macrophages	(Wagener et al. 2014)