Table 1.

A list of NSAIDs (19 active drugs and one prodrug) approved by FDA and TPSA (Ų) values.

No	Drug name	PubChem CID	Mechanism of action	TPSA (< 140 Å2)
1	Flubiprofen	3394	Nonselective COX inhibitor	37.30
2	Ibuprofen	3672	Nonselective COX inhibitor	37.30
3	Indomethacin	3715	Nonselective COX inhibitor	68.53
4	Ketorolac	3826	Nonselective COX inhibitor	59.30
5	Mefenamic acid	4044	Nonselective COX inhibitor	49.33
6	Piroxicam	54,676,228	Nonselective COX inhibitor	107.98
7	Diflunisal	3059	Prostaglandin synthesis inhibitor	57.53
8	Fenoprofen	3342	Prostaglandin synthesis inhibitor	46.53
9	Naproxen	156,391	Prostaglandin synthesis inhibitor	46.53
10	Sulindac	1,548,887	Prostaglandin synthesis inhibitor	73.58
11	Tolmetin	5509	Prostaglandin synthesis inhibitor	59.30
12	Ketoprofen	3825	Selective COX-1 inhibitor	54.37
13	Oxaprozin	4614	Selective COX-1 inhibitor	63.33
14	Celecoxib	2662	Selective COX-2 inhibitor	86.36
15	Rofecoxib	5090	Selective COX-2 inhibitor	68.82
16	Valdecoxib	119,607	Selective COX-2 inhibitor	94.57
17	Diclofenac	3033	Selective COX-2 inhibitor	49.33
18	Etodolac	3308	Selective COX-2 inhibitor	62.32
19	Meloxicam	54,677,470	Selective COX-2 inhibitor	136.22
20a	6MNA	32,176	Selective COX-2 inhibitor	46.53

^a6MNA (Active form) of Nabumetone (Prodrug); TPSA (Topological Polar Surface Area).