Table 2.
Target proteins in 26 signaling pathways enrichment related to COVID-19.
| KEGG ID & description | Target proteins | Rich factor | False discovery rate |
|---|---|---|---|
| hsa04014: Ras signaling pathway | MAPK8, MAPK10, BAD | 0.013157895 | 0.0071 |
| hsa04921: Oxytocin signaling pathway | PTGS2, PPP1CA | 0.013422819 | 0.0294 |
| hsa04010: MAPK signaling pathway | MAPK8, MAPK10, MAPK14, CASP3 | 0.013651877 | 0.0016 |
| hsa04310: WNT signaling pathway | MAPK8, MAPK10 | 0.013986014 | 0.0276 |
| hsa04022: cGMP -PKG signaling pathway | ENDRA, BAD, PPP1CA | 0.01875 | 0.003 |
| hsa04064: NF-kappa B signaling pathway | CXCL8, PTGS2 | 0.021505376 | 0.0136 |
| hsa04926: Relaxin signaling pathway | MAPK8, MAPK10, MAPK14 | 0.023076923 | 0.0018 |
| hsa04068: FoxO signaling pathway | MAPK8, MAPK10, MAPK14 | 0.023076923 | 0.0018 |
| hsa04071: Sphingolipid signaling pathway | MAPK8, MAPK10, MAPK14 | 0.025862069 | 0.0014 |
| hsa04910: Insulin signaling pathway | MAPK8, MAPK10, BAD, PPP1CA | 0.029850746 | 0.00013 |
| hsa04621: NOD-like receptor signaling pathway | MAPK8, MAPK10, MAPK14, CXCL8, CASP1 | 0.030120482 | 0.0000197 |
| hsa04024: cAMP signaling pathway | ENDRA, MAPK8, BAD, MAPK10, PPP1CA, PPARA | 0.030769231 | 0.00000373 |
| hsa04912: GnRH signaling pathway | MAPK8, MAPK10, MAPK14 | 0.034090909 | 0.00072 |
| hsa04722: Neurotrophin signaling pathway | MAPK8, MAPK10, MAPK14, BAD | 0.034482759 | 0.00000853 |
| hsa04012: ErbB signaling pathway | MAPK8, MAPK10, BAD | 0.036144578 | 0.00062 |
| hsa04620: Toll-like receptor signaling pathway | MAPK8, MAPK10, MAPK14, CXCL8 | 0.039215686 | 0.0000581 |
| hsa03320: PPAR signaling pathway | PPARA, PPARG, FABP2 | 0.041666667 | 0.00044 |
| hsa04920: Adipocytokine signaling pathway | MAPK8, MAPK10, PPARA | 0.043478261 | 0.00041 |
| hsa04917: Prolactin signaling pathway | MAPK8, MAPK10, MAPK14 | 0.043478261 | 0.00041 |
| hsa04664: Fc epsilon RI signaling pathway | MAPK8, MAPK10, MAPK14 | 0.044776119 | 0.00039 |
| hsa04668: TNF signaling pathway | MAPK8, MAPK10, MAPK14, CASP3, PTGS2 | 0.046296296 | 0.00000413 |
| hsa04370: VEGF signaling pathway | MAPK8, MAPK10, BAD | 0.050847458 | 0.00029 |
| hsa04933: AGE-RAGE signaling pathway in diabetic complications | MAPK8, MAPK10, MAPK14, CXCL8, CASP1 | 0.051020408 | 0.00000373 |
| hsa04622: RIG-I-like receptor signaling pathway | MAPK8, MAPK10, MAPK14, CXCL8 | 0.057142857 | 0.0000197 |
| hsa04657: IL-17 signaling pathway | MAPK8, MAPK10, MAPK14, CXCL8, CASP3, PTGS2 | 0.065217391 | 0.000000135 |
| hsa05120: Epithelial cell signaling in Helicobacter pylori infection | MAPK8, MAPK10, MAPK14, CXCL8, CASP3 | 0.075757576 | 0.000000954 |