Table 2.

Comprehensive HLA haplotype analysis of HLA-A, -C and -B in Japanese severe COVID-19 and Japanese healthy control.

Locus	Allele	Control (2n=846) %	Severe_COVID (2n=106)%	OR (95% CI)	p.value	p.corrected
A~C~B	24:02:01:01~07:02:01:03~07:02:01:01	5.8	0.9	0.16 (0.00-0.93)	0.035	NS
A~C~B	24:02:01:01~12:02:02:01~52:01:01:02	8.9	17.0	2.09 (1.12-3.72)	0.008	0.033
A~C~B	33:03:01:01~14:03:01:01~44:03:01:10	7.6	6.6	0.85 (0.32-1.93)	0.703	NS
A~C~B	binned	77.7	75.5	0.89 (0.54-1.48)	0.611	NS
C~B	01:02:01:05~54:01:01:01	7.9	6.6	0.83 (0.31-1.87)	0.645	NS
C~B	03:03:01:01~35:01:01:02	5.9	4.7	0.79 (0.24-2.03)	0.621	NS
C~B	03:04:01:02~40:02:01:01	5.2	3.8	0.71 (0.18-2.02)	0.524	NS
C~B	07:02:01:03~07:02:01:01	6.8	3.8	0.54 (0.14-1.49)	0.228	NS
C~B	12:02:02:01~52:01:01:02	9.4	18.9	2.25 (1.24-3.92)	0.003	0.020
C~B	14:02:01:01~51:01:01:01	5.8	5.7	0.98 (0.33-2.36)	0.958	NS
C~B	14:03:01:01~44:03:01:10	8.2	6.6	0.79 (0.30-1.78)	0.564	NS
C~B	binned	50.8	50.0	0.97 (0.63-1.48)	0.875	NS
A~C	24:02:01:01~07:02:01:03	5.8	0.9	0.16 (0.00-0.93)	0.035	NS
A~C	24:02:01:01~12:02:02:01	9.0	17.0	2.06 (1.11-3.67)	0.010	0.039
A~C	33:03:01:01~14:03:01:01	7.8	6.6	0.84 (0.32-1.90)	0.674	NS
A~C	binned	77.4	75.5	0.90 (0.55-1.50)	0.650	NS
A~B	24:02:01:01~07:02:01:01	5.9	0.9	0.15 (0.00-0.91)	0.032	NS
A~B	24:02:01:01~52:01:01:02	9.0	17.0	2.06 (1.11-3.67)	0.010	0.039
A~B	33:03:01:01~44:03:01:10	7.6	6.6	0.85 (0.32-1.93)	0.703	NS
A~B	binned	77.4	75.5	0.90 (0.55-1.50)	0.650	NS

Significant HLA haplotypes after multiple correction are highlighted in bold.

OR, odd ratio; 95% CI, 95% confidence interval; Pc-value, multiple testing corrected p-value; binned, rare HLA alleles with expected count < 5 are combined into a common class