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. 2021 Apr 22;12:671966. doi: 10.3389/fimmu.2021.671966

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Copyright © 2021 Mathä, Martinez-Gonzalez, Steer and Takei

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Upon activation by allergens, cytokines or helminths in the lung or small intestine (SI), ILC2s and inflammatory ILC2s (iILC2s) appear in circulation as well as in the tissue-draining lymph nodes (LN). SI-derived iILC2s migrate to the lung, whereas the destination of activated SI and lung ILC2s is currently unclear. Although ILC2s and iILC2s are detected in blood and LN, which suggests that their migration involves lymphatics and blood, the exact route of migration has yet to be determined.