Table 1.
Summary of ILC2 phenotypes.
Mouse | Human | |||||
---|---|---|---|---|---|---|
Lung | Intestine | Skin | Liver | Fat | Blood | |
CD127 | + | + | + | + | + | + |
CD90 | + | + | + | + | + | − |
CD25 | + | + | + | + | + | + |
CD103 | ND | ND | + | ND | ND | − |
IL-18Rα | − | − | + | − | − | + |
ST2 | + | low | +/low | + | + | − |
IL-25R | low | + | +/low | ND | − | − |
CRTH2* | + | |||||
CD161* | + | |||||
GATA3 | + | + | + | + | + | + |
“+”, expressed; “−”, not expressed; “low”, expressed at low levels; “+/low”, various reports exist; “ND”, not determined. *human ILC2 markers. Human ILC2 phenotype is based on peripheral blood ILC2s.