. 2021 Feb 21;59(1):69–80. doi: 10.1002/jmd2.12202

TABLE 1.

Characteristics of patients and controls

	Patients (total)	Classical PKU	MHPA	BH₄‐sensitive PKU	Controls	P
Number (n)	49	25	10	14	98
Gender
Male (n)	26	13	5	8	52	1.000 ^a
Female (n)	23	12	5	6	46	1.000 ^a
Age (years) Median [IQR]	9 [4.5; 14.0]	8 [3.5; 13.5]	8.5 [3.0; 15.3]	11.5 [6.8; 14.3]	10 [4.0; 13.3]	.768 ^a
BMI (kg/m ² ) Median [IQR]	17.7 [16.2; 19.0]	17.1 [16.0; 18.8]	17.4 [16.2; 20.6]	18.3 [16.9; 19.9]	17.9 [16.1; 19.7]	.763 ^a
WSI‐Index ^b Median [IQR]	13 [10.0; 15.0]	12 [9.0; 14.0]	12.5 [6.0; 14.5]	13 [11.8; 19]	14 [11.3; 16.0] ^e	.046 ^a
Median mean dried blood Phe concentration (μmol/L) at study visit [IQR]	213 [152; 398]	306 [138; 499]	207 [141; 212]	224 [173; 365]	n. a.	.233
Median mean dried blood Phe concentration (μmol/L) 1 year prior enrollment [IQR]	231 [199; 437]	250 [215; 577]	186 [163; 213]	261 [217; 360]	n. a.	.003 ^c
Median Phe tolerance ^f (mg/day) [IQR]	450 ^g [339; 1000]	400 ^h [260; 480]	n. a.	1170 ⁱ [1000; 1200]	n. a	<.001 ^d

Note: The P values in bold letters represent significant differences (P < .05).

Abbreviations: MHPA, mild hyperphenylalaninemia; n. a, not applicable; PKU, phenylketonuria.

^{^a}

Comparison between patients (total) vs controls, Mann‐Whitney‐U‐test.

^{^b}

WSI stratification Index: lower class 3‐8, middle class 9‐14, upper class 15‐21.

^{^c}

Comparison between patients with classical PKU vs BH₄‐sensitive PKU vs MHPA, Kruskal‐Wallis‐test.

^{^d}

Comparison between patients with classical PKU vs BH₄‐sensitive PKU, Mann‐Whitney‐U‐test.

^{^e}

n = 88.

^{^f}

Applicable for PKU patients on diet.

^{^g}

n = 30.

^{^h}

n = 23.

^ⁱ

n = 7.