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. 2021 Apr 22;11:659321. doi: 10.3389/fonc.2021.659321

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Copyright © 2021 Zhang, Gu, Su, Bai, Guan, Ma, Luo, He, Zhang, Geng, Xia, Guan, Shen and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunobiology features of NOTCH/co-DDR co-occurrence. (A) Heatmap of immune infiltration in each patient. (B) Volcano plots for the enrichment (red) and depletion (blue) of immune cell types for GoodBenefit and BadBenefit. The expression levels of genes were first z-score normalized across all patients. Then we calculated the mean z-scores for each group and ranked in descending order. Based on the pre-ranked GSEA method, for each immune cell signature, we defined the q-value <10% and NES >0 as the enrichment, while the q-value <10% and NES <0 as the depletion. Immune cells with absolute NES greater than 1 were shown. (C) Normalized express of immune-related genes between Goodbenefit versus Badbenefit.