Figure 2.

ILC based immunotherapeutics and mouse models as tools to study them. Immunotherapies that involve ILC antitumor activity can be categorized as antibody-based, cell-based, or other bioengineered immunomodulators. Mouse models such as PD-1 and CTLA-4 knock-in can be used to study checkpoint inhibitors. SCID mice bearing PDX or CDX can be used to study the efficacy of single agent cell therapies such as CAR NK cells or NK92 cells. HIS mice are the most optimal tool to study combination therapies or immunomodulators that may alter the behavior of multiple immune cell types.