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. 2021 Apr 22;8:668910. doi: 10.3389/fmolb.2021.668910

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Copyright © 2021 Alam, Bröms, Kumar and Sjöstedt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A summary of ClpB’s so-far established roles in pathogenic bacteria, including T6S (Francisella only). Schematic figure illustrating the importance of ClpB in various stress responses, T6S and virulence. Model of the T6S in extended (left), contracted (central), and disassembled (right) forms of canonical and Francisella T6S is shown, where ClpB acts as an energizer. Canonical T6S subunits from Escherichia coli are labeled in black and Francisella T6S subunits, which are encoded within the Francisella Pathogenicity Island (FPI), are labeled in blue.