TABLE 1.
Effect of ncRNAs on the function of placental trophoblasts.
| NcRNA | The function of trophoblast | References |
|---|---|---|
| lncRNA NEAT1 | Overexpression of NEAT1 inhibits the proliferation, migration, invasion, and colony formation of trophoblast cells, and promotes apoptosis | Teng et al. (2020) |
| miR-181a-5p, miR-378, miR-663, miR-483-3p, miR-514, miR-181a-3, miR-892, miR-34c, and miR-454 | Affect the proliferation of trophoblast cells | Arthurs et al. (2019) |
| circPAPPA | Knockout of circPAPPA results in reduced proliferation and invasion of HTR8-S/Vneo trophoblast cells | Zhou et al. (2019) |
| MicroRNALet-7a | Inhibition of tumorigenicity and enhancement of apoptosis of JEG-3 cells | Zha et al. (2020) |
| MiR-124–3p | Inhibits the invasion and migration of trophoblast cells and promotes apoptosis partly through the PLGF-ROS pathway | Tao et al. (2020) |
| MiR-193b | Targets IGFBP5 to inhibit autophagy and apoptosis of trophoblasts induced by high glucose | Ji et al. (2020) |
| miR-133 | Affects the apoptosis of trophoblasts in placental tissue | Zhang WM et al., 2019 |
| MiR-125b | Targets MCL1 to induce apoptosis of HTR8/SVneo cells | Gu et al. (2019) |
| MiR-200c | Regulation of placental trophoblast apoptosis in rats with preeclampsia | Zhang X. et al. (2019) |
| MiR-183 | Inhibition of trophoblast migration and invasion | Lai and Yu. (2020) |
| MiR-125b | Regulation of migration and invasion of extravillous trophoblast cells | Tang et al. (2021) |
| MiR-215–5p | Reduces the ability of trophoblast to migrate and invade | Yang and Meng. (2020) |
| miR-181b-5p | Regulation of trophoblast migration and invasion | Miao et al. (2020) |
| MiR-384 | Regulation of proliferation and migration of trophoblast cells | Zhou et al. (2020) |
| MicroRNA-125b | Inhibits the invasion of cytotrophoblasts and damages endothelial cell function | Li Q et al. (2020) |
| miRNA-29b | Inhibit the growth and migration of trophoblasts | Sun et al. (2020) |
| LncRNA HOTAIR | Inhibits trophoblast proliferation, migration and invasion | Zhao et al. (2020) |
| CircTRNC18 | Inhibition of trophoblast cell migration and epithelial-mesenchymal transformation | Shen et al. (2019) |
| lncRNA H19 | Regulation of angiogenesis of EVTs | Zeng et al. (2020) |
| lncRNA TUG1 | Promotes trophoblast proliferation, invasion, and angiogenesis, and inhibits apoptosis | Li et al. (2019) |