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. 2021 Apr 22;12:660198. doi: 10.3389/fimmu.2021.660198

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Copyright © 2021 Riley, Chou, Hu, Bzymek, Correia, Partin, Li, Gong, Wang, Yu, Manzanillo and Garces

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Trimer formation of rationally designed disulfides. SEC chromatograms (left) and corresponding structural models (right, with zoom-in) of each of the top four disulfide designs. RCC3 (A), RCC4 (B), RCC5 (C), and RCC6 (D) each migrate on the SEC primarily as a trimer with a peak corresponding to a 669kDa MW standard (Standard elution traces shown in grey). Residues that form the engineered disulfide are shown as spheres the overall view of each model, and as sticks in each zoomed-in view.