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Involvement of Notch, Hedgehog, and Wnt signaling pathways in the resistance of cancer cells to Radiotherapy: Radiotherapy often induces Notch, Hedgehog, and Wnt signaling in cancer, which in turn regulates the key molecules involved in DNA repair, cell-cycle, cell survival, ROS generation, EMT, and CSC, that leads to the acquisition of radioresistance in cancer.
