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. 2021 Apr 22;12:666334. doi: 10.3389/fphar.2021.666334

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Copyright © 2021 Bubb, Ravindran, Cartland, Finemore, Clayton, Tsang, Tang, Kavurma, Patel and Figtree.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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β₃AR stimulation improves glucose tolerance and recovery from post-ischemic injury in type 2 diabetes. (A) Schematic of the type 2 diabetes (T2D) protocol. (B) Glucose tolerance tests in a cohort of citrate-buffer control (n = 3–4) and T2D mice treated with vehicle or CL 316,243 (n = 4–5). (C) Area under the curve (AUC) analysis of glucose tolerance results. (D) Ischemic to non-ischemic ratio of perfusion in citrate-buffer treated control (n = 12) and T2D (n = 13) mice measured by laser doppler imaging. Data presented as mean ± SEM; *p < 0.05, **p < 0.01, ***p < 0.001 vs. vehicle by 2-way ANOVA.