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. 2021 Apr 22;9:642605. doi: 10.3389/fcell.2021.642605

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Copyright © 2021 Xu, Yao, Ni, Zheng, Huang, Huang, Gao, Qiao, Shen and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockdown of miR-411-5p recovered sh-circSIPA1L1-induced impairment of cell growth, invasion, and migration of OS cells. (A) Both 143B and HOS cells were stably transfected with N.C., sh-circSIPA1L1, or co-transfected with sh-circSIPA1L1 and miR-411-5p sponge. Migration-related assays were employed to evaluate the cell invasion and migration abilities of OS cells. (B) Wound-healing experiment validated the recovery of migration capacity by miR-411-5p sponge. (C) Downregulation of circSIPA1L1 and miR-411-5p during cell proliferation was confirmed by CCK-8 assays. (D) Effects of circSIPA1L1 silencing on OS cell growth were removed by miR-411-5p inhibition. (E) Apoptosis assay demonstrated the reversal of cell survival ability by miR-411-5p sponge. Data from 3 independent experiments are presented as mean ± SD. *P < 0.05.