Table 3.
PiGeOn participants' knowledge, attitude, and psychological outcomes over 12 months.
| Variable | Baseline (T0) (n = 353) | 3- month (T1) (n = 346) | 12-month (T2) (n = 285) | Significance test, p-value |
|---|---|---|---|---|
| Perceived importance of genome sequencing | ||||
| Mean (SD) | 3.76 (0.55) | |||
| Range | 1.4–5.0 | |||
| Knowledge of genomics | ||||
| Mean (SD) | 0.47 (0.24) | |||
| Range | 0–1 | |||
| Perceived ability to cope with genome sequencing results | ||||
| Mean (SD) | 4.17 (0.67) | |||
| Range | 1–5 | |||
| Intention to change behavior if gene variant indicating cancer risk was found | ||||
| Mean (SD) | 4.25 (0.66) | |||
| Range | 1–5 | |||
| Attitude towards uncertainty | ||||
| Mean (SD) | 4.03 (0.68) | |||
| Range | 1.57–5 | |||
| Fear of cancer recurrence | ||||
| Mean (SD) | 13.76 (815) | 12.36 (7.94) | 11.89 (8.15) | F(1.90, 494.21)=10.26, p = 0.000 |
| Range | 0–30 | 0–30 | 0–30 | |
| Perceived susceptibility of (another) cancer | ||||
| Mean (SD) | 64.78 (16.44) | 65.09 (16.33) | 65.87 (17.82) | F(1.94, 503.19) = 0.69, p = 0.500 |
| Satisfaction with decision to have genome sequencing | ||||
| Mean (SD) | 26.17 (3.17) | 26.74 (3.89) | 26.33 (4.13) | F(1.93, 494.50)=2.33, p = 0.100 |
| Genome sequencing anxiety | ||||
| Mean (SD) | 5.78 (9.94) | 6.38 (11.82) | t(265) = −1.160, p = 0.247 | |
| General anxiety and depressive symptoms | ||||
| Mean (SD) | 7.98 (6.66) | 8.53 (7.30) | t(265)=-1.610, p = 0.109 | |
| Anxiety subscale | ||||
| Mean (SD) | 5.15 (4.09) | 5.48 (4.44) | t(265)= −1.617, p = 0.107 | |
| Depression subscale | ||||
| Mean (SD) | 2.83 (3.25) | 3.04 (3.45) | t(265) = −1.205, p = 0.229 | |
| Hope | ||||
| Mean (SD) | 39.30 (5.52) | 39.23 (6.07) | t(211) = 0.203, p = 0.839 | |
| Distress | ||||
| Mean (SD) | 22.34 (9.49) | 23.20 (10.29) | t(210) = −1.354, p = 0.177 | |
| Perceived uncertainty about genome sequencing | ||||
| Mean (SD) | 8.23 (7.37) | 7.95 (7.64) | t(210) = 0.660, p=0.510 | |