Table 1.
Baseline characteristics of patients with cancer treated with immune checkpoint inhibitors and matched controls
| Characteristics | ICI group, n = 1,545 | Control group, n = 20,418 | p value |
|---|---|---|---|
| Sex: female, n (%) | 648 (41.9) | 8,564 (41.9) | >.999 |
| Age, years | >.999 | ||
| Mean (SD) | 66.6 (12.0) | 66.6 (12.0) | |
| 18–44, n (%) | 952 (4.7) | 72 (4.7) | |
| 45–64, n (%) | 6,965 (34.1) | 527 (34.1) | |
| 65–74, n (%) | 7,480 (36.6) | 566 (36.6) | |
| ≥75, n (%) | 5,022 (24.6) | 380 (24.6) | |
| Race,b n (%) | >.999 | ||
| White, non‐Hispanic | 1,447 (93.7) | 19,123 (93.7) | |
| Asian, non‐Hispanic | 33 (2.1) | 436 (2.1) | |
| Black, non‐Hispanic | 32 (2.1) | 423 (2.1) | |
| Other, non‐Hispanic | 12 (0.8) | 159 (0.8) | |
| Hispanic | 1 (0.1) | 13 (0.1) | |
| Unknown | 20 (1.3) | 264 (1.3) | |
| CCI grade, n (%) | .13 | ||
| Mild (1–2) | 52 (3.4) | 834 (4.1) | |
| Moderate (3–4) | 357 (23.1) | 5,017 (24.6) | |
| Severe (≥5) | 1,136 (73.5) | 14,567 (71.3) | |
| Cancer type, n (%) | |||
| Hematologic cancer | 111 (7.2) | 1,467 (7.2) | >.999 |
| Solid organ cancer | 1,485 (96.1) | 19625 (96.1) | >.999 |
| Comorbidities, n (%) | |||
| Congestive heart failure | 165 (10.7) | 2,371 (11.6) | .27 |
| Hypertension | 822 (53.2) | 9,452 (46.3) | <.001 |
| Diabetes mellitus | 254 (16.4) | 4,204 (20.6) | <.001 |
| Chronic obstructive pulmonary disease and bronchiectasis | 373 (24.1) | 4,477 (21.9) | .04 |
| Other chronic pulmonary disease | 233 (15.1) | 3,766 (18.4) | <.001 |
| Renal disease | 241 (15.6) | 3,290 (16.1) | .59 |
| Liver disease | 535 (34.6) | 6,452 (31.6) | .01 |
| Rheumatic disease | 52 (3.4) | 926 (4.5) | <.001 |
| Inflammatory bowel disease | 29 (1.9) | 720 (3.5) | .03 |
| Median income in $1,000s | .002 | ||
| Missing, n | 12 | 144 | |
| Mean (SD) | 79.6 (26.8) | 81.9 (28.6) | |
| COVID‐19 town or county positivity rate per 100, mean (SD) | 1.37 (0.89) | 1.38 (0.91) | .68 |
| COVID‐19 positive, n (%) | 22 (1.4) | 213 (1.0) | .16 |
| Died, n (% of COVID‐19 positive) | 9 (40.9) | 61 (28.6) | .23 |
a
As recorded in the electronic medical record.
Abbreviations: CCI, Charlson Comorbidity Index; COVID‐19, coronavirus disease‐19.