Table 2.
Multivariate analysis using a Cox proportional hazards model for overall survival predictors
| Variables | P value | Hazard ratio (95% CI) |
|---|---|---|
| Hypothyroidism | .018 | 2.53 (1.177–5.439) |
| Sex | .583 | 0.814 (0.391–1.696) |
| Age >65 years | .204 | 0.641 (0.323–1.272) |
| HBsAg positive | .353 | 1.424 (0.676–3.002) |
| Anti‐HCV positive | .577 | 0.79 (0.345–1.808) |
| Macrovascular invasion | .035 | 2.066 (1.053–4.052) |
| AFP >400 ng/mL | .138 | 1.61 (0.858–3.022) |
| Extrahepatic spread | .040 | 1.977 (1.033–3.784) |
| Child‐Pugh B (vs. A) | .262 | 1.991 (0.598–6.625) |
| ECOG PS 0 (vs. 1 or 2) | .245 | 0.696 (0.378–1.281) |
| Prior HCC treatment | .006 | 0.388 (0.197–0.764) |
Abbreviations: AFP, α‐fetoprotein; ECOG PS, Eastern Cooperative Oncology Group performance status; HBsAg, hepatitis B virus surface antigen; HCC, hepatocellular carcinoma; HCV, hepatitis C virus.