Capecitabine
Generic/Working Name	Capecitabine
Trade Name	Xeloda
Company Name	Roche
Drug Type	Fluoropyrimidine with antineoplastic activity
Drug Class	Antimetabolite
Dose	1,000 milligrams (mg) per squared meter (m2)
Route	Oral (p.o.)
Schedule of Administration	Capecitabine was administered at 1,000 mg/m2 by mouth twice daily. The dose of capecitabine was calculated with a maximum body surface area (BSA) of 2.0 m2 for patient safety. Capecitabine dose was adjusted if BSA changed >5% from baseline.
Sorafenib
Generic/Working Name	Sorafenib
Trade Name	Nexavar
Company Name	Bayer and Onyx Pharmaceutics
Drug Type	Small molecule
Drug Class	Tyrosine kinase inhibitor
Dose	200 milligrams
Route	Oral (p.o.)
Schedule of Administration	Sorafenib was administered at 200 mg by mouth twice daily. Dose was increased to 400 mg by mouth each morning and 200 mg by mouth each evening (dose level + 1) for cycle 2, and then to 400 mg by mouth twice daily (dose level + 2) for cycle 3 and onward, assuming no attributable AEs during the prior cycle.