TABLE 2.

Biomarkers and other baseline characteristics.

	Intervention
	LPV/r	HCQ	LPV/r + HCQ	SoC	p-value a	Total
	N = 124	N = 109	N = 243	N = 112		N = 588
Neutrophils, N	4.2 (2.9, 6.4)	4.0 (2.8, 5.8)	3.7 (2.7, 5.6)	4.8 (3.2, 6.9)	0.031	4.1 (2.8, 5.9)
Neutrophils, %	72.0 (62.3, 82.3)	67.9 (57.9, 77.5)	70.1 (60.3, 79.7)	69.4 (56.0, 78.4)	0.095	69.9 (59.6, 79.7)
Total lymphocytes, N	1.0 (0.7, 1.4)	1.2 (0.9, 1.8)	1.1 (0.8, 1.4)	1.4 (1.0, 1.9)	<0.001	1.1 (0.8, 1.6)
Total lymphocytes, %	17.5 (11.1, 26.9)	22.6 (14.4, 30.5)	21.0 (12.8, 28.3)	20.5 (13.1, 31.2)	0.079	20.5 (12.7, 28.4)
Aspartate amino-transferase (AST), U/L	32.0 (23.5, 42.5)	25.0 (19.0, 41.0)	28.0 (22.0, 42.0)	24.0 (18.0, 38.0)	0.002	27.0 (21.0, 41.0)
Alanine amino-transferase (ALT), U/L	26.0 (18.5, 43.5)	22.0 (14.0, 41.0)	26.5 (16.0, 40.0)	22.0 (14.0, 35.0)	0.072	24.0 (16.0, 40.0)
Bilirubin, mg/L	0.6 (0.5, 0.9)	0.6 (0.5, 0.8)	0.7 (0.5, 1.0)	0.7 (0.5, 1.0)	0.003	0.7 (0.5, 0.9)
Hemoglobin, mg/L	13.8 (12.7, 14.9)	12.9 (11.6, 14.0)	13.7 (12.7, 15.0)	13.2 (11.6, 14.6)	<0.001	13.6 (12.3, 14.7)
Creatinine, mg/L	0.9 (0.8, 1.1)	0.9 (0.7, 1.0)	0.9 (0.8, 1.1)	0.9 (0.7, 1.1)	0.083	0.9 (0.8, 1.1)
D-dimer, mg/L	790.0 (423.0, 1254)	698.0 (436.0, 1245)	660.0 (441.0, 1266)	796.5 (435.0, 1501)	0.923	711.0 (437.0, 1299)
Lactate dehydrogenase, U/L	267.0 (217.0, 368.0)	224.0 (177.0, 282.0)	251.0 (202.0, 326.0)	203.0 (166.0, 264.0)	<0.001	245.0 (192.0, 311.0)
C-reactive protein, mg/L	3.4 (1.5, 9.8)	2.4 (1.2, 7.0)	3.7 (1.6, 8.8)	1.8 (0.2, 4.7)	<0.001	3.0 (1.2, 8.0)
Platelets, 109/L	198.0 (158.5, 274.0)	231.0 (181.0, 309.0)	207.0 (161.0, 276.0)	234.5 (173.5, 289.5)	0.068	217.0 (167.0, 284.5)
Potassium, mmol/L	3.7 (3.4, 3.9)	3.7 (3.3, 3.9)	3.6 (3.4, 3.8)	3.7 (3.4, 4.0)	0.388	3.6 (3.4, 3.9)
Ferritin, mg/L	374.0 (176.0, 839.0)	297.0 (104.0, 637.0)	536.5 (266.5, 1045)	277.5 (128.5, 602.5)	<0.001	427.5 (186.0, 841.0)

All values are expressed as median (IQR).

^aKruskal–Wallis test.