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. 2021 Apr 22;12:647296. doi: 10.3389/fneur.2021.647296

Table 1.

Semi-quantitative (SQ) grading conventions at a glance.

Nakashima et al. (19) Gürkov et al. (24) Yang et al. (25) Baráth et al. (20) Attyé et al. (81) Kirsch et al. (22) Boegle et al. (present data) Bernaerts et al. (21) Bernaerts and de Foer (23)
COCHLEA
Slice of evaluation Midmodiolar level Not specified Midmodiolar level Same as Nakashima et al. (19) Midmodiolar level Midmodiolar level
Grade 0 No displacement of RM, interscalar septum, scala tympani, cochlear duct, scala vestibuli visible No enlargement of ELS, PLS is clearly visible No displacement of RM, interscalar septum, scala tympani, cochlear duct, scala vestibuli visible “X-mas tree” made of circles with “very thin, clear, hypointense line” (cp. Figure 1A). “Very thin, clear, hypointense line” (=non-enhancing scala media or ELS) between clearly enhancing scala vestibuli and scala tympani (=PLS)
Grade 1 Displacement of RM, cochlear duct < scala vestibuli ELS is enlarged and bulging into PLS Irregular dilation and partial obstruction of the scala vestibuli, cochlear duct indirectly visible as nocular black cut-out of the scala vestibuli “X-mas tree” with “X-mas lights”, where ELS is slightly enlarged and indirectly visible as a nodular black cut out (cp. Figure 1B). “X-mas tree” (=enhancing scala vestibuli and scala tympani) with “X-mas balls” (=nodular enlargement non-enhancing scala media)
Grade 2 Displacement of RM, cochlear duct > scala vestibuli Scala media is scalloping into the scala tympani, PLS has a semicircular appearance “X-mas tree” with “X-mas balls”, where ELS is bulding into scala tympani whilst giving the PLS a semicircular appearance (cp. Figure 1C).
Grade 3 A severely distended scala media causes a flattened appearance of the perilymph space No scala vestibuli visible “X-mas tree” with “X-mas garlands”, where ELS is distended and causes a flattened appearance of the PLS (cp. Figure 1D). “X-mas tree” (=enhancing scala vestibuli and scala tympani) with “X-mas garlands” (=linear enlarged non-enhancing scala media)
VESTIBULUM
Slice of evaluation Lowest slice of vestibulum L-SCC still visible Same as Nakashima et al. (19) Midmodiolar level Axial slice through inferior part of vestibulum Vestibulum inferior part; L-SCC still visible Vestibulum inferior part
Grade 0 AR <33.3% AR <50%, sacculus and utriculus are distinguishable SURI <1, no saccular abnormality Sacculus < utriculus, otoliths still distinguishable (cp. Figure 1A). AR <50%,sacculus < utriculus, otoliths are distinguishable
Grade 1 33.3% < AR <50% SURI ≥1 Sacculus (sign should remain as is) utriculus, otoliths are still distinguishable (cp. Figure 1B). Sacculus ≥ utriculus, otoliths are distinguishable
Grade 2 AR >50% AR >50%, PLS remains visible with circular rim enhancement No sacculus visible Sacculus & utriculus are confluent, PLS rim visible (cp. Figure 1C). Sacculus and utriculus are confluent, PLS remains visible with circular rim enhancement
Grade 3 No PLS visible No otolith organs distinguishable, no PLS visible (cp. Figure 1D). No PLS visible

AR, area ratio; ELS, endolymphatic space; L-SCC, lateral semicircular canal; PLS, perilymphatic space; SURI, ratio ≥ 1 between the area of the sacculus and the area of the utriculus, RM, Reissner's membrane. The bold text highlights the main or most important characteristics.