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. 2021 Apr 22;12:647296. doi: 10.3389/fneur.2021.647296

Table 5.

SQ-specific 2D- and 3D-quantification of the ELS.

Grade 0 Grade 1 Grade 2 Grade 3
No hydrops Mild hydrops Marked hydrops Severe hydrops
Mean ± std (min–max) Mean ± std (min–max) Mean ± std (min–max) Mean ± std (min–max)
(A) 2D-quantification
c6 Inner ear [mm2] R1-3 2.15 ± 1.32 (0.25–4.81) 3.57 ± 1.81 (0.19–6.81) 5.91 ± 1.92 (2.44–9.75) 6.31 ± 2.75 (3.19–8.38)
Cochlea [mm2] R1-3 0.56 ± 0.40 (0–1.31) 0.96 ± 0.77 (0–3) 1.29 ± 0.72 (0.06–2.56) 1.78 ± 0.13 (1.69–1.88)
Vestibulum [mm2] R1-3 1.88 ± 1.24 (0.13–4.25) 2.67 ± 1.62 (0–5.63) 4.18 ± 1.68 (1.13–8.63) 5.89 ± 2.04 (2.56–8)
c8 Inner ear [mm2] R1-3 3.08 ± 1.54 (0.63–6.00) 4.77 ± 2.07 (0.5–8.5) 7.59 ± 2.20 (3.25–11.13) 8.19 ± 3.32 (4.38–10.44)
Cochlea [mm2] R1-3 0.89 ± 0.51 (0.25–1.94) 1.38 ± 0.92 (0.13–3.88) 1.76 ± 0.89 (0.19–3.31) 2.59 ± 0.04 (2.56–2.63)
Vestibulum [mm2] R1-3 2.45 ± 1.39 (0.31–5.19) 3.45 ± 1.84 (0.13–6.81) 5.34 ± 1.84 (1.88–9.44) 7.13 ± 2.30 (3.19–9)
c10 Inner ear [mm2] R1-3 4.46 ± 1.87 (1.44–7.63) 6.01 ± 2.27 (1.19–10.63) 9.07 ± 2.28 (4.38–12.75) 9.77 ± 3.26 (6.06–12.19)
Cochlea [mm2] R1-3 1.31 ± 0.54 (0.56–2.13) 1.84 ± 1.00 (0.44–4.44) 2.25 ± 1.00 (0.44–3.88) 3.22 ± 0.04 (3.19–3.25)
Vestibulum [mm2] R1-3 3.21 ± 1.64 (0.56–6.38) 4.24 ± 1.98 (0.56–8) 6.25 ± 1.98 (2.19–10.13) 8.10 ± 2.56 (3.81–10.31)
TFS Cochlea [mm2] R1-3 15.54 ± 1.49 (12.63–18.63) 16.64 ± 1.20 (14.13–9.63) 16.59 ± 2.48 (9.63–21.88) 16.50 ± 1.24 (15.63–17.38)
Vestibulum [mm2] R1-3 19.45 ± 2.92 (15.00–24.63) 20.63 ± 2.66 (15.63–25.5) 20.78 ± 2.13 (17.31–25.19) 21.74 ± 3.03 (18–25.5)
c6 Inner ear ER [%] R1-3 6.10 ± 3.74 (0.85–13.68) 9.54 ± 4.72 (0.64–17.76) 15.71 ± 4.90 (5.58–25.12) 16.99 ± 7.20 (8.73–21.93)
Cochlea ER [%] R1-3 3.51 ± 2.43 (0.00–7.78) 5.67 ± 4.33 (0–16.78) 7.93 ± 4.35 (0.29–14.96) 10.80 ± 0.01 (10.79–10.8)
Vestibulum ER [%] R1-3 9.50 ± 6.43 (0.82–21.79) 12.78 ± 7.61 (0–25.07) 20.09 ± 7.76 (5.96–40.83) 27.02 ± 8.95 (12.97–37.10)
c8 Inner ear ER [%] R1-3 8.78 ± 4.36 (2.12–17.05) 12.75 ± 5.29 (1.71–21.55) 20.20 ± 5.64 (6.91–28.50) 22.10 ± 8.95 (11.99–29.00)
Cochlea ER [%] R1-3 5.65 ± 3.09 (1.44–11.48) 8.22 ± 5.14 (0.78–21.38) 10.83 ± 5.34 (0.86–18.90) 15.75 ± 0.91 (15.11–16.4)
Vestibulum ER [%] R1-3 12.49 ± 7.18 (2.08–26.60) 16.46 ± 8.52 (0.79–30.36) 25.71 ± 8.55 (9.93–44.67) 32.72 ± 10.1 (16.14–41.74)
c10 Inner ear ER [%] R1-3 12.70 ± 5.20 (4.88–21.67) 16.10 ± 5.75 (4.06–27.96) 24.16 ± 5.91 (9.30–31.88) 26.35 ± 8.60 (16.61–32.90)
Cochlea ER [%] R1-3 8.34 ± 3.33 (3.94–15.25) 10.95 ± 5.58 (2.23–24.49) 13.84 ± 6.11 (2.57–21.99) 19.57 ± 1.74 (18.35–20.80)
Vestibulum ER [%] R1-3 16.34 ± 8.41 (3.75–32.69) 20.31 ± 9.01 (3.54–37.85) 30.07 ± 9.20 (11.59–47.93) 37.15 ± 10.9 (19.30–47.83)
(B) 3D-quantification
c6 Inner ear [mm3] R1-3 11.17 ± 3.85 (2.70–19.11) 14.52 ± 4.97 (7.48–27.97) 22.78 ± 5.54 (13.50–32.76) 23.13 ± 8.61 (13.50–30.10)
Cochlea [mm3] R1-3 3.15 ± 1.23 (0.76–6.20) 4.65 ± 2.93 (1.5–12.91) 6.49 ± 2.51 (2.89–11.80) 10.62 ± 2.62 (8.77–12.46)
Vestibulum [mm3] R1-3 8.27 ± 3.25 (1.38–14.53) 10.43 ± 3.63 (4.52–17.96) 14.81 ± 4.68 (5.56–25.53) 18.23 ± 5.43 (10.19–24.39)
c8 Inner ear [mm3] R1-3 16.59 ± 5.24 (4.81–26.95) 20.73 ± 6.03 (11.02–36.47) 30.61 ± 6.78 (19.10–44.54) 31.16 ± 10.2 (19.78–39.56)
Cochlea [mm3] R1-3 4.58 ± 1.60 (1.31–8.11) 6.57 ± 3.51 (2.67–16.14) 8.73 ± 3.00 (4.59–14.70) 13.39 ± 3.22 (11.11–15.67)
Vestibulum [mm3] R1-3 12.29 ± 4.39 (2.56–20.86) 14.78 ± 4.48 (7–23.98) 20.12 ± 5.42 (9.48–30.26) 24.53 ± 6.49 (14.78–30.87)
c10 Inner ear [mm3] R1-3 23.06 ± 6.63 (7.97–35.78) 27.87 ± 6.83 (15.34–44.95) 38.85 ± 8.05 (24.97–56.85) 39.68 ± 11.5 (27.13–49.73)
Cochlea [mm3] R1-3 6.38 ± 2.03 (2.05–10.05) 8.74 ± 3.96 (4.02–18.84) 11.12 ± 3.38 (6.19–18.26) 16.15 ± 4.24 (13.16–19.15)
Vestibulum [mm3] R1-3 17.10 ± 5.45 (4.64–27.53) 19.78 ± 5.19 (9.52–29.81) 25.78 ± 6.15 (14.06–36.55) 31.28 ± 7.41 (20.41–38.59)
TFS Cochlea [mm3] R1-3 90.0 ± 10.6 (68.96–105.82) 95.4 ± 11.2 (74.25–117.52) 99.90 ± 14.1 (75.5–124.47) 97.1 ± 17.6 (84.63–109.56)
Vestibulum [mm3] R1-3 178.6 ± 18.3 (149.7–219.7) 181.2 ± 23.3 (132.2.0.0.221.7) 176.8 ± 18.2 (140.3–227.3) 190.4 ± 11.2 (175.0–199.6)
c6 Inner ear ER [%] R1-3 4.12 ± 1.23 (1.15–6.25) 5.32 ± 1.83 (2.90–9.82) 8.05 ± 1.68 (4.46–10.73) 8.25 ± 2.84 (4.98–9.94)
Cochlea ER [%] R1-3 3.49 ± 1.48 (1.10–8.19) 4.76 ± 2.67 (1.49–12.02) 6.55 ± 2.46 (2.59–11.11) 10.87 ± 0.72 (10.36–11.38)
Vestibulum ER [%] R1-3 4.57 ± 1.63 (0.87–7.07) 5.82 ± 2.04 (2.43–9.62) 8.30 ± 2.26 (3.57–13.20) 9.51 ± 2.51 (5.60–12.22)
c8 Inner ear ER [%] R1-3 6.13 ± 1.66 (2.04–8.82) 7.60 ± 2.21 (4.44–12.81) 10.83 ± 2.04 (6.18–14.11) 11.12 ± 3.32 (7.29–13.15)
Cochlea ER [%] R1-3 5.07 ± 1.86 (1.90–10.71) 6.76 ± 3.17 (2.78–15.03) 8.81 ± 2.90 (3.88–13.85) 13.71 ± 0.83 (13.13–14.3)
Vestibulum ER [%] R1-3 6.79 ± 2.17 (1.62–10.14) 8.24 ± 2.54 (3.99–12.84) 11.30 ± 2.53 (6.09–16.61) 12.81 ± 2.96 (8.12–15.47)
c10 Inner ear ER [%] R1-3 8.53 ± 2.07 (3.38–11.71) 10.20 ± 2.47 (6.19–15.79) 13.75 ± 2.42 (8.28–17.95) 14.16 ± 3.61 (10.0–16.25)
Cochlea ER [%] R1-3 7.04 ± 2.25 (2.98–13.26) 9.03 ± 3.52 (4.21–17.54) 11.24 ± 3.29 (5.36–16.24) 16.51 ± 1.37 (15.55–17.48)
Vestibulum ER [%] R1-3 9.48 ± 2.66 (2.94–13.39) 11.01 ± 2.95 (5.99–15.97) 14.50 ± 2.79 (9.03–20.09) 16.35 ± 3.29 (11.22–19.42)