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. 2021 Apr 22;11:682017. doi: 10.3389/fonc.2021.682017

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Copyright © 2021 Yuan, Ji, Shi, Shi, Liu, Wu, Yang, Xi, Li, Zhu, Li, Gong and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Comparison of TMB distribution among N, P1, P2, and P3 groups. (B) The TMB distribution of different cancers in the population is shown according to PD-L1 high and low groups. (C) TMB value of each sample in each cancer type. Shades of purples indicate the different levels of PD-L1 expression, while grays indicate PD-L1 negative samples. (D) The number and proportion of PD-L1 high and low samples in Hypermutation and Low groups. P < 0.05 was considered a significant difference, ^* P < 0.05, ^** P < 0.01, ^**** P < 0.0001. NS, not significant.