Fig. 2.

Mutational landscape in advanced HCC by ctDNA profiling.

(A) The percentages of HCC patients that were positive for each mutated gene detected in ctDNA. TERT mutations were detected by ddPCR and other mutations were detected by NGS sequencing. (B) The VAF for each mutated gene in each HCC patient. Bars show median value of VAF. (C) Heat map shows ctDNA VAF and CTC count in each of the 26 HCC patients. VAF, variant allele frequency. (D) The VAF of mutated genes in ctDNA and matched tumor tissue.