Table 3.

Deregulated circulating ncRNAs in cancer cachexia and the pathway that are possibly implicated in (strong experimental evidence), according to miRPathDB v2.0 [75].

ncRNA	Pathway possibly implicated in	Expression	Circulation	Reference
hsa-miR-21	Cancer, regulation of catalytic activity	Increased	Lung or pancreatic cancer-derived exosomes	[113]
			Serum from cachectic patients with colorectal cancer	[91]
hsa-miR-155	Chromosome, nuclear lumen	Increased	Breast cancer-derived exosomes	[109]
hsa-miR-92a-3p	Activation of BIM and translocation to mitochondria	Increased	Chronic myeloid leukemia-derived exosomes	[111]
hsa-miR-130a	Negative regulation of blood vessel endothelial cell migration	Decreased	Plasma from cachectic patients with head and neck cancer	[90]
hsa-miR-203	Hepatitis B, Pancreatic cancer, Androgen receptor signaling pathway	Increased	Serum from patients with colorectal cancer	[92]
hsa-miR-486	Role of phospholipids in phagocytosis	Decreased	Serum from patients with breast cancer	[73]
ciRS-133	Circular RNA sponge for miR-133	Increased	Gastric cancer-derived exosomes	[65]